Do not take probiotics indefinitely for general wellness if you are healthy
A review of 45 trials in healthy adults found no lasting change to the gut microbiome from routine probiotics: changes generally faded after supplementation stopped, and blood lipids did not improve. Specific uses, such as preventing antibiotic-associated diarrhea, have a separate evidence base and are outside this entry.
What it takes
About RMB 2–5 a day, or 700–1,800 a year.
What you may gain
A review of 45 trials in healthy adults found no consistent lasting improvement in the gut microbiome or lipid profile. Some changes were temporary and reversed after use ended. “Gut health” is a broad, appealing promise, and a modest daily cost can make indefinite use feel reasonable even when a concrete benefit has not been established.
Context & considerations
Some studies found modest improvements in stool consistency or vaginal lactobacilli. Probiotics for antibiotic-associated diarrhea, or a particular strain used for a particular condition, are separate questions. This entry concerns healthy people taking them every day for unspecified wellness benefits.
Research & references
Khalesi S et al. (2019). A review of probiotic supplementation in healthy adults: helpful or hype? European Journal of Clinical Nutrition. https://doi.org/10.1038/s41430-018-0135-9.